PDZ

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Examples of PDZ domain-containing proteins (Figure from Lee et al. 2010). Proteins are indicated by black lines scaled to the length of the primary sequence of the protein.

The PDZ domain (post-synaptic density protein PSD95, disc large Dlg, and zonula occludens Zo) is a common structural domain of 80-90 amino-acids found in thousands of signaling proteins of bacteria, yeast, plants, viruses and animals. These domains help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes (e.g. the PDZ domains in the PSD-95 protein associate with SH3 domain-containing proteins). In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation (the beta sheet in the PDZ domain is extended by the addition of another beta strand from the partner binding protein's tail).


Proteins containing this domain

There are roughly 260 human PDZ domains (virus has 1 known PDZ protein - Tax1), though since several PDZ domain-containing proteins hold several domains, the actual number of PDZ proteins is closer to 180. Listed below are some of the better studied members of this family:

  • Cystic fibrosis transmembrane conductance regulator (CFTR)
  • Erbin
  • HTRA1
  • HTRA2
  • HTRA3
  • DLG4 aka PSD-95
  • SAP97
  • CARD11
  • PTPN13

List of PDZ Domain Proteins

AAG12; AHNAK; AHNAK2; AIP1; ALP; APBA1; APBA2; APBA3; ARHGAP21; ARHGAP23; ARHGEF11; ARHGEF12; CASK; CLP-36; CNKSR2; CNKSR3; DFNB31; DLG1; DLG2; DLG3; DLG4; DLG5; DVL1; DVL1L1; DVL2; DVL3; ERBB2IP; FRMPD1; FRMPD2; FRMPD2L1; FRMPD3; FRMPD4; GIPC1; GIPC2; GIPC3; GOPC; GRASP; GRIP1; GRIP2; HTRA1; HTRA2; HTRA3; HTRA4; IL16; INADL; KIAA1849; LDB3; LIMK1; LIMK2; LIN7A; LIN7B; LIN7C; LMO7; LNX1; LNX2; LRRC7; MAGI1; MAGI2; MAGI3; MAGIX; MAST1; MAST2; MAST3; MAST4; MCSP; MLLT4; MPDZ; MPP1; MPP2; MPP3; MPP4; MPP5; MPP6; MPP7; MYO18A;  ;NOS1; PARD3; PARD3B; PARD6A; PARD6B; PARD6G; PDLIM1; PDLIM2; PDLIM3; PDLIM4; PDLIM5; PDLIM7; PDZD11; PDZD2; PDZD3; PDZD4; PDZD5A; PDZD7; PDZD8; PDZK1; PDZRN3; PDZRN4; PICK1; PPP1R9A; PPP1R9B; PREX1; PRX; PSCDBP; PTPN13; PTPN3; PTPN4; RAPGEF2; RAPGEF6; RGS12; RGS3; RHPN1; RIL; RIMS1; RIMS2; SCN5A; SCRIB; SDCBP; SDCBP2; SHANK1; SHANK2; SHANK3; SHROOM2; SHROOM3; SHROOM4; SIPA1; SIPA1L1; SIPA1L2; SIPA1L3; SLC9A3R1; SLC9A3R2; SNTA1; SNTB1; SNTB2; SNTG1; SNTG2; SNX27; SPAL2; STXBP4; SYNJ2BP; SYNPO2; SYNPO2L; TAX1BP3; TIAM1; TIAM2; TJP1; TJP2; TJP3; TRPC4; TRPC5; USH1C; WHRN;