Reaction Rate Math

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The rate at which molecules interact to form a bound complex is called the association rate; conversely the rate at which a bound complex breaks down into constituent parts is called the dissociation rate.

   association rate:  kon  or    k+  µM-1s-1
   dissociation rate:  koff  or    k-  s-1

The affinity of this binding is:

   affinity constant: KA = 1 / KD = kon / koff

Binding is reversible, with a dissociation constant of:

   dissociation constant: KD = 1 / KA = koff / kon