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PKA or Protein Kinase A

1. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs)

2. cAMP molecules bind and release each PKA regulatory subunit.

3. catalytic subunits phosphorylate Ser and Thr residues

4. PKA can directly activate CREB, which binds CRE, altering the transcription