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{{Article|Lu, Shi, Nicoll|2009|Cell - [http://www.sciencedirect.com/science/article/pii/S0896627309002554 FullText]|19409270|Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach}} | |||
; FIGURE 1 | |||
Outside-Out Patch Recordings of AMPAR-Mediated Current from CA1 Pyramidal Neurons in GluA2 KO and WT Mice | |||
(A) (Top) Example of the strongly inwardly rectifying I/V curve of glutamate-evoked AMPAR-mediated current, in the presence of 100 μM cyclothiazide, from acute hippocampal slice from the germline 2- to 3-week-old GluA2-KO mouse, with an RI value of 0.16. (Bottom) In a subsequent glutamate application in the same OOP, held at −60 mV, ∼99% of the current could be blocked by 100 nM PhTx-433. | |||
(B) Example of the linear I/V curve of glutamate-evoked current in a WT littermate, with an RI value of 0.83. (Bottom) In the same OOP, glutamate-evoked current was untouched by 100 nM PhTx-433. | |||
(C) Bar graph showing average RI values for each of the genotypes: GluA2-KO mice, RI = 0.12 ± 0.02 (n = 9); WT mice, RI = 0.82 ± 0.02 (n = 15). | |||
(D) Bar graph showing the average percent block (%) of glutamate-evoked currents by 100 nM PhTx-433 in GluA2-KO mice; average percent block is 97.9% ± 0.4% (n = 6) and, in WT mice, 0% (n = 5). | |||
[[Category:Synaptic Plasticity]] [[Category:Journals]] | |||
Latest revision as of 19:03, 20 March 2015
Lu, Shi, Nicoll • 2009 • Cell - FullText
- FIGURE 1
Outside-Out Patch Recordings of AMPAR-Mediated Current from CA1 Pyramidal Neurons in GluA2 KO and WT Mice (A) (Top) Example of the strongly inwardly rectifying I/V curve of glutamate-evoked AMPAR-mediated current, in the presence of 100 μM cyclothiazide, from acute hippocampal slice from the germline 2- to 3-week-old GluA2-KO mouse, with an RI value of 0.16. (Bottom) In a subsequent glutamate application in the same OOP, held at −60 mV, ∼99% of the current could be blocked by 100 nM PhTx-433. (B) Example of the linear I/V curve of glutamate-evoked current in a WT littermate, with an RI value of 0.83. (Bottom) In the same OOP, glutamate-evoked current was untouched by 100 nM PhTx-433. (C) Bar graph showing average RI values for each of the genotypes: GluA2-KO mice, RI = 0.12 ± 0.02 (n = 9); WT mice, RI = 0.82 ± 0.02 (n = 15). (D) Bar graph showing the average percent block (%) of glutamate-evoked currents by 100 nM PhTx-433 in GluA2-KO mice; average percent block is 97.9% ± 0.4% (n = 6) and, in WT mice, 0% (n = 5).
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