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| {{Article|Lu, Gray, Granger, During, Nicoll|2011|J Neurophysiol - [http://www.ncbi.nlm.nih.gov/pubmed/20980546 PDF]|20980546|Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit}} | | {{Article|Lu, Gray, Granger, During, Nicoll|2011|J Neurophysiol - [http://www.ncbi.nlm.nih.gov/pubmed/20980546 PDF]|20980546|Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit}} |
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| We thus tested whether GluA2 is required for the potentiation of AMPAR EPSCs following the loss of NMDARs. In the GRIA2fl/fl mice, deleting GluA2 caused about a 50% reduction in the AMPAR EPSC {{Fig| [[File:Nicoll2011 Fig1.png]] }} with no change in the glutamate-evoked AMPAR-mediated outside-out patch currents (B ). Interestingly, in GRIA2fl/flGRIN1fl/fl mice the loss of NMDARs failed to enhance AMPAR EPSCs. In fact, there was a significant further decrease {{Fig| [[File:Nicoll2011 Fig1.png]] }}. Neither genetic manipulation changes the PPR. In addition, as expected, deletion of GluA2 caused strong inward rectification. Finally, no difference was found in glutamate evoked AMPAR-mediated currents in outside-out patches {{Fig| [[File:Nicoll2011 Fig1.png]] }}. Therefore in contrast to GluA1, the GluA2 subunit is critical for synaptic potentiation of AMPARs following NMDAR deletion.
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| {{Article|Honkura, Matsuzaki, Noguchi, Ellis-Davies, Kasai|2008|Cell • [http://www.sciencedirect.com/science/article/pii/S0896627308000743 FullText]|18341992|The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.}}
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| <mediaplayer image='http://www.bradleymonk.com/w/images/d/da/Kasai_GluUncaging_S7.png' width='500' height='300'>http://www.bradleymonk.com/w/images/1/18/Kasai_GluUncaging_S7.mov</mediaplayer>
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| Two-photon imaging of the confinement of PAGFP-actin fluorescence after repetitive photoactivation and uncaging of MNI-glutamate (60 pulses of 0.6 ms duration at 1 Hz) at a point (square) distal to the apex of the spine shown in Figure 5D. The 2D images were acquired every 10 s for 7 min. Photoactivation was induced at the moment when the white square turns red. Scale bar, 1 μm. </div></html>||<big>SI video1 </big>}}
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| Two-photon imaging of PAGFP-actin fluorescence after repetitive photoactivation and uncaging of MNI-glutamate (60 pulses of 0.6 ms duration at 1 Hz) at a point (square) distal to the apex of the spine shown in Figure 5G in the presence of Lat A (0.1 μM). The 2D images were acquired every 15 s for 10 min. Photoactivation was induced at the moment when the white square turns red. Scale bar, 1 μm. </div></html>||<big>SI video1 </big>}}
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Roger Nicoll UCSF Profile
Lu, Gray, Granger, During, Nicoll
• 2011 • J Neurophysiol - PDF
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{{Article|AUTHORS|YEAR|JOURNAL • [PDF_LINK PDF]|PUBMED_ID|TITLE_OF_ARTICLE}}
;Figure #
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[[Category:Synaptic Plasticity]] [[Category:Journals]]
{{Ref|Ehrlich Malinow|14749436}}
{{Fig| [[File:Nicoll2011 Fig1.png]] }}
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