Molecular Memory: Difference between revisions

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(Changing image note: 1. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs) 2. cAMP molecules bind and release each PKA regula)
(Adding image note: Ca2+/calmodulin-dependent protein kinases II are serine/threonine-specific protein kinases that are regulated by the calmodulin complex.)
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4. PKA can directly activate CREB, which binds CRE, altering the transcription
4. PKA can directly activate CREB, which binds CRE, altering the transcription
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Ca2+/calmodulin-dependent protein kinases II are serine/threonine-specific protein kinases that are regulated by the calmodulin complex. CaMKII phosphorylates AMPA receptors at the P2 serine 831 site. This increases channel conductance of GluA1 subunits of AMPA receptors.
CaMKII has also been shown to aid in the process of AMPA receptor exocytosis. CaMKII activity leads to endosomal docking at the membrane.
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Revision as of 23:31, 14 April 2013

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