Hippocampus: Difference between revisions
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[[File:Hippocampus.gif|thumb|400px|The hippocampal Network: The hippocampus forms a principally uni-directional network, with input from the Entorhinal Cortex (EC) tht forsms connections with the Dentate Gyrus (DG) and CA3 pyramidal neurons via the Perforant Path (PP - split into lateral and medial). CA3 neurons also receive input from the DG via the Mossy Fibres (MF). They send axons to CA1 pyramidal cells via the Schaffer Collateral Pathway (SC), as well as to CA1 cells in the contralateral hippocampus via the Associational Commisural (AC) Pathway. CA1 neurons also receive inputs direct from the Perforant Path and send axons to the Subiculum (Sb). These neurons in turn send the main hippocampal output back to the EC, forming a loop.]] | [[File:Hippocampus.gif|thumb|400px|The hippocampal Network: The hippocampus forms a principally uni-directional network, with input from the Entorhinal Cortex (EC) tht forsms connections with the Dentate Gyrus (DG) and CA3 pyramidal neurons via the Perforant Path (PP - split into lateral and medial). CA3 neurons also receive input from the DG via the Mossy Fibres (MF). They send axons to CA1 pyramidal cells via the Schaffer Collateral Pathway (SC), as well as to CA1 cells in the contralateral hippocampus via the Associational Commisural (AC) Pathway. CA1 neurons also receive inputs direct from the Perforant Path and send axons to the Subiculum (Sb). These neurons in turn send the main hippocampal output back to the EC, forming a loop.]] | ||
[[File:Perirhinal-network.gif|thumb|400px|Perirhinal-LEC-hippocampus | |||
The perirhinal cortex sends projections to the lateral entorhinal cortex (LEC). This innervation runs from and to the superficial layers (layers II and III). These in turn project to the CA1-subiculum junction as part of the LEC projection to the hippocampus, part of the perforant path. Reciprocal projections return to the LEC, but to deeper layers (layer V), with intra-LEC connections closing the loops. Postrhinal-MEC-hippocampus: Similar to the perirhinal cortex, the postrhinal cortex sends also projections to the entorhinal cortex, but in this case to the medial entorhinal cortex (MEC). This innervation again runs from and to the superficial layers (layers II and III). These in turn project to the proximal CA1 (nearer to CA3) and the distal subiculum as part of the perforant path. Reciprocal projections return to layer V of the MEC, with intra-MEC connections closing the loops]] | |||