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{{Box|width=46%|float=left|font-size=14px|[[ | {{Box|width=46%|float=left|font-size=14px|[[Actin|Actin Modeling]]| | ||
The study of actin dynamics is centrally important to understanding synaptic plasticity. Fortunately, actin research has provided a vast pool of experimental studies, and several refined (time-hardened) quantitative models that provide excellent characterizations of actin polymerization kinetics. To simulate filament scaffolding in the unified model, I’ve developed what’s probably best described as a stochastic 3D model (S3D model) of actin dynamics based on parameters from previously established in steady-state (Bindschadler 2004192 Yarmola 2008193), monte carlo (Halavatyi 2008193) and stochastic (Mogilner 2006 194) models. My motivation for developing an actin model is to harmonize with these established actin models wherever possible, and to validate the actin dynamics component for use in the unified model. Also, the simulation of the stochastic evolution of actin networks in 3D makes this model the first of its kind. | |||
<mediaplayer image='http://www.bradleymonk.com/w/images/d/da/Kasai_GluUncaging_S7.png' width='500' height='300'>http://www.bradleymonk.com/w/images/1/18/Kasai_GluUncaging_S7.mov</mediaplayer> | |||
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{{Box|width=47%|float= | {{Box|width=46%|float=left|Welcome to the official wiki of Brad Monk| | ||
[[Hello]] and welcome to [[User:Monakhos|my wiki]]. This is where I stash random information and have every intention of linking it all together someday. I'm not sure why you're here.. maybe trying to find one of my other wiki projects '''[http://onesci.com OneSci Science News]''' or '''[http://ucsd.onesci.com UCSD Psych Grad wiki]'''? If you are so inclined, recent additions to this wiki can be found in the box on the right. For a non-curated glimpse of my activity you can check out the [[Special:RecentChanges|latest wiki updates]]. Older wiki [[content]] can be accessed using the <nowiki>[search box]</nowiki> or perusing [[Special:AllPages| all pages]]. If you would like to contact me, you can find this info on [http://bradleymonk.com my home page]. | |||
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{{Box|width=47%|float=right|font-size=14px|[[Brain Molecular Pathways|Brain Molecular Pathways Project]]| | |||
This project aims to provide annotated sets of [[Molecular Pathways|molecular pathways]] involved in neural plasticity underlying learning and memory systems. In general, biological pathways display the series of interactions among molecules resulting in functional changes within cells and neural networks. Currently there are large scale projects dedicated to amassing pathway evidence via high-throughput methods. The goal is to translate this unwieldy biopathway data from several [http://www.genome.jp/kegg/ empirical databases] into visually digestible material, by [[Molecular Pathways|characterizing]] the features of molecular cascades most sensitive to an ''event of interest'' (e.g. fear conditioning or amphetamine addiction). | This project aims to provide annotated sets of [[Molecular Pathways|molecular pathways]] involved in neural plasticity underlying learning and memory systems. In general, biological pathways display the series of interactions among molecules resulting in functional changes within cells and neural networks. Currently there are large scale projects dedicated to amassing pathway evidence via high-throughput methods. The goal is to translate this unwieldy biopathway data from several [http://www.genome.jp/kegg/ empirical databases] into visually digestible material, by [[Molecular Pathways|characterizing]] the features of molecular cascades most sensitive to an ''event of interest'' (e.g. fear conditioning or amphetamine addiction). | ||
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Revision as of 01:50, 25 April 2015
Welcome to the official wiki of Brad Monk