File:Sheng Hoogenrad 2007 Fig3.jpg

Domain structure, stoichiometry, and function of major PSD proteins. The copy number per average PSD (“stoichiometry”) is shown where it has been measured (70). Because of space limitations, this list is not comprehensive and not all relevant references are cited. The proteins are not drawn to scale because of large differences in protein size. Red circles indicate PDZ domains, and black boxes indicate transmembrane domains. Abbreviations: Ank, ankyrin repeats; Arm, armadillo/beta-catenin-like repeats; CA, cadherin repeat domain; CH, calponin homology domain, actin binding; CK, calcium/calmodulin-dependent kinase domain; EFh, EF-hand, calcium-binding domain; ELHD, esterase and lipase homology domain; EVH1, Homer type EVH1 domain; GK, guanylate kinase; GKAP, guanylate-kinase-associated protein; GTP-CDC, GTP-cell division protein; L27, L27 domain; PA, protein kinase A anchor; PH, pleckstrin homology domain; RapGAP, GTPase-activator protein for Rap/Ran-like GTPases; RasGAP, GTPase-activator protein for Ras-like GTPases; RhoGEF, guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; SAM, sterile alpha motif; Sec14, Sec14p-like lipid-binding domain; SH3, Src homology 3 domains; Spectrin, spectrin repeat.