File:Sheng Hoogenrad 2007 Fig4.jpg

Figure 4

Organization of proteins and protein-protein interactions in the postsynaptic density (PSD). Schematic diagram of the network of proteins in the PSD, with edge of PSD depicted at right. Only major families and certain classes of PSD proteins are shown [in approximate stoichiometric ratio and scaled to molecular size, if known (see text)]. Contacts between proteins indicate an established interaction between them. Domain structure is shown only for PSD-95 (PDZ domain, SH3 domain, GuK domain). Other scaffold proteins are colored yellow; signaling enzymes, green; actin binding proteins, pink. CaMKII (calcium/calmodulin-dependent protein kinase II ) is depicted as dodecamer. Unnamed proteins signify the many other PSD proteins that are not illustrated in this diagram. Abbreviations: AKAP150, A-kinase anchoring protein 150 kDa; CAM, cell adhesion molecule; Fyn, a Src family tyrosine kinase; GKAP, guanylate kinase-associated protein; H, Homer; IRSp53, insulin receptor substrate 53 kDa; KCh, K+ channel; mGluR, metabotropic glutamate receptor; nNOS, neuronal nitric oxide synthase; RTK, receptor tyrosine kinases (e.g., ErbB4, TrkB); SPAR, spine-associated RapGAP.