File:Hoze Choquet Holcman 2012.png

Figure 1

Fig. 1. Stochastic analysis of superresolution trajectories for AMPARs. (A) 30,000 trajectories of GluA1-containing AMPARs located on the surface membrane, three regions of interest are marked. (B) The overlay of the highest receptor densities (red) with the hippocampal confocal neuronal image reveals that these regions colocalize with the synaptic marker Homer (white spots). (C) Map of diffusion coefficient (extracted from [Eq. 3]). (D) Median diffusion coefficients in dendritic spines (sampled over 3,341 points) and in the dendritic shaft (9,385 points). Davg is the average diffusion coefficient. (E) Three disjoint interacting potentials (obtained from [Eq. 2]) marked in (A)–(C). (F) Field of forces in the neuronal membrane. (G) Three potential well patterns, characterized by a converging force, (extracted from E) quantified using the index S, confirming that the wells are due to direct interactions.