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Figure 2

Figure 2. Scaffold proteins of the PSD and their domains. Major scaffold proteins and cytoskeleton-associated proteins of the PSD of excitatory synapses, scaled approximately by size. Act, actin-binding; Ank, ankyrin repeats; ArfGAP, GTPase-activating protein for Arf small GTPase; CC, coiled coil; CH, calponin homology; CK, calmodulin-dependent kinase (CaMK)-like domain; CRIB, Cdc42/Rac interactive-binding; EFh, EF-hand; EVH1, Ena/VASP homology 1; GH1, GKAP homology 1; GK, guanylate kinaselike domain; GKBD, GKAPbinding domain; GRKBD, GRK2-binding domain; GTP-CDC, GTP-cell division protein; L27, domain initially found in LIN-2 and LIN-7; LRR, leucine-rich repeat; PDZ domains are shown as red ellipses. PH, pleckstrin homology; RapGAP, GTPase-activating protein for Rap small GTPases; RasGAP, GTPase-activating protein for Ras small GTPases; RCB, Rac binding;SAM, sterile alpha motif; SH3, Src homology 3;SHD, Spa2 homology domain; Spectrin, spectrin repeat; ST, subcellular targeting domain;WW, domain with two conserved Trp (W) residues.