PKA
(Redirected from Protein Kinase A)
PKA or Protein Kinase A
1. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs)
2. cAMP molecules bind and release each PKA regulatory subunit.
3. catalytic subunits phosphorylate Ser and Thr residues
4. PKA can directly activate CREB, which binds CRE, altering the transcription