LTP Pathway: Difference between revisions

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(Adding image note: Arc, for activity-regulated cytoskeleton-associated protein (also known as Arg3.1), is a plasticity protein first characterized in 19)
(Removing image note: PKA or Protein Kinase A 1. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs) 2. cAMP molecules)
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There are some minor PKA-independent functions of cAMP, e.g., activation of calcium channels, providing a minor pathway by which growth hormone-releasing hormone causes a release of growth hormone.
There are some minor PKA-independent functions of cAMP, e.g., activation of calcium channels, providing a minor pathway by which growth hormone-releasing hormone causes a release of growth hormone.
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[[PKA]] or [[Protein Kinase A]]
1. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs)
2. cAMP molecules bind and release each PKA regulatory subunit.
3. catalytic subunits phosphorylate Ser and Thr residues
4. PKA can directly activate CREB, which binds CRE, altering the transcription
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[[CaMKII]] -- Ca2+/calmodulin-dependent protein kinases II are serine/threonine-specific protein kinases that are regulated by the calmodulin complex. CaMKII phosphorylates AMPA receptors at the P2 serine 831 site. This increases channel conductance of GluA1 subunits of AMPA receptors.
[[CaMKII]] -- Ca2+/calmodulin-dependent protein kinases II are serine/threonine-specific protein kinases that are regulated by the calmodulin complex. CaMKII phosphorylates AMPA receptors at the P2 serine 831 site. This increases channel conductance of GluA1 subunits of AMPA receptors.

Revision as of 23:45, 14 April 2013

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