LTP Pathway: Difference between revisions

Revision as of 00:47, 15 April 2013

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LTP Pathway LTP Pathway

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-[[Arc]], for activity-regulated cytoskeleton-associated protein (also known as Arg3.1), is a plasticity protein first characterized in 1995. Arc is a member of the immediate-early gene (IEG) family, a rapidly activated class of genes functionally defined by their ability to be transcribed in the presence of protein synthesis inhibitors. Arc mRNA is localized to activated synaptic sites in an NMDA receptor-dependent manner, where the newly translated protein is believed to play a critical role in learning and memory-related molecular processes. Arc is widely considered to be an important protein in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. Along with other IEGs such as zif268 and Homer 1a, Arc is also a significant tool for systems neuroscience as illustrated by the development of the cellular compartment analysis of temporal activity by fluorescence in situ hybridization, or catFISH technique (see fluorescent in situ hybridization).
+[[PKA]] or [[Protein Kinase A]]
+. concentration of cAMP rises (e.g., activation of adenylate cyclase via GPCR-Gs)
+. cAMP molecules bind and release each PKA regulatory subunit.
+. catalytic subunits phosphorylate Ser and Thr residues
+. PKA can directly activate CREB, which binds CRE, altering the transcription
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